清华-IDG/麦戈文脑科学研究院讲座：Tien-Chen Lin 谈从振荡细胞骨架到稳定神经元极性
清华-IDG/麦戈文脑科学研究院讲座系列：Tien-Chen Lin
德国神经退行性疾病中心（DZNE）博士后 Tien-Chen Lin 将于 2026 年 11 月 12 日 14:00-15:30 在清华大学生物医学馆 E109 作报告，主题为从振荡细胞骨架到稳定神经元极性。他利用活体成像、基因功能缺失、光遗传学控制与局部细胞骨架扰动，发现胞体起始的 ARP2/3 依赖性肌动蛋白分支振荡程序协调轴突选择。该研究将神经元极化重新定义为动态的全细胞过程。
时间: 2026年11月12日14:00-15:30
地点：生物医学馆E109会议室
Information 讲座信息
Tien-Chen Lin
German Center for Neurodegenerative Diseases (DZNE) in Bonn
Host
Dr. Song-Hai Shi (时松海）
Topic
From oscillating cytoskeletons to stable neuronal polarity
Abstract
Neurons acquire polarity by selecting one neurite as the axon while the others become dendrites, yet how this asymmetry is established remains unclear. Using live imaging and genetic loss-of-function approaches in vivo, together with optogenetic control and local cytoskeletal perturbations in cultured neurons, we identified a soma-initiated oscillatory program that coordinates axon selection. Periodic ARP2/3-dependent actin branching remodels a global actomyosin network, generating recurrent cycles of neurite extension and retraction that transiently bias individual neurites toward axon fate. As polarization proceeds, one neurite escapes this oscillatory regime and enters persistent growth, while actomyosin activity continues to constrain competing neurites. These findings recast neuronal polarization as a dynamic whole-cell process. I will discuss how this cytoskeletal oscillator establishes neuronal polarity and how transient differences in growth may subsequently be converted into stable axonal and dendritic identities.
Biography
Tien-Chen Lin is a postdoctoral researcher in Frank Bradke’s laboratory at the German Center for Neurodegenerative Diseases (DZNE) in Bonn. He trained in biochemistry and microtubule biology at the University of Heidelberg, where he studied the regulation and assembly of microtubule-nucleation machinery. At DZNE, he shifted to neuronal cell biology and led a 2026 Nature study identifying a soma-initiated ARP2/3–actomyosin oscillatory program that establishes neuronal polarity. His current work investigates how transient cytoskeletal dynamics are converted into stable neuronal compartment identities using quantitative imaging, spatial perturbation, mechanistic biochemistry and mathematical modeling.
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IDG/McGovern Institute
for Brain Research at Tsinghua
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公众号：THU_McGovern
官方网站：http://mcgovern.life.tsinghua.edu.cn/ch/
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